4n9c: Difference between revisions

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'''Unreleased structure'''


The entry 4n9c is ON HOLD
==Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)==
<StructureSection load='4n9c' size='340' side='right'caption='[[4n9c]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4n9c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9C FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.751&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2ZM:5-NITRO-1H-BENZIMIDAZOLE'>2ZM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9c OCA], [https://pdbe.org/4n9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9c RCSB], [https://www.ebi.ac.uk/pdbsum/4n9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9c ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).


Authors: Dragovich, P.S., Zhao, G., Baumeister, T., Bravo, B., Giannetti, A.M., Ho, Y., Hua, R., Li, G., Liang, X., O'Brien, T., Skelton, N.J., Wang, C., Zhao, Q., Oh, A., Wang, W., Wang, Y., Xiao, Y., Yuen, P., Zak, M., Zheng, X.
==See Also==
 
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
Description: Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Baumeister T]]
[[Category: Bravo B]]
[[Category: Dragovich PS]]
[[Category: Giannetti AM]]
[[Category: Ho Y]]
[[Category: Hua R]]
[[Category: Li G]]
[[Category: Liang X]]
[[Category: O'Brien T]]
[[Category: Oh A]]
[[Category: Skelton NJ]]
[[Category: Wang C]]
[[Category: Wang W]]
[[Category: Wang Y]]
[[Category: Xiao Y]]
[[Category: Yuen P]]
[[Category: Zak M]]
[[Category: Zhao G]]
[[Category: Zhao Q]]
[[Category: Zheng X]]
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