3w0u: Difference between revisions
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== | ==human Glyoxalase I with an N-hydroxypyridone inhibitor== | ||
[[http://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN | <StructureSection load='3w0u' size='340' side='right'caption='[[3w0u]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3w0u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W0U FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HPW:N-[3-(1-HYDROXY-6-OXO-4-PHENYL-1,6-DIHYDRO-PYRIDIN-2-YL)-5-METHANESULFONYLAMINO-PHENYL]-METHANESULFONAMIDE'>HPW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0u OCA], [https://pdbe.org/3w0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w0u RCSB], [https://www.ebi.ac.uk/pdbsum/3w0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w0u ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref> | |||
== | ==See Also== | ||
[[ | *[[Glyoxalase 3D structures|Glyoxalase 3D structures]] | ||
== References == | |||
== | <references/> | ||
<references | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Fukami | [[Category: Large Structures]] | ||
[[Category: Irie | [[Category: Fukami TA]] | ||
[[Category: Matsuura | [[Category: Irie M]] | ||
[[Category: Matsuura T]] | |||
Latest revision as of 12:45, 8 November 2023
human Glyoxalase I with an N-hydroxypyridone inhibitor
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