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{{STRUCTURE_4imf|  PDB=4imf  |  SCENE=  }}
===Crystal Structure of Pasteurella multocida N-Acetyl-D-Neuraminic acid lyase K164 mutant complexed with N-Acetylneuraminic acid===
{{ABSTRACT_PUBMED_24152047}}


==Function==
==Crystal Structure of Pasteurella multocida N-Acetyl-D-Neuraminic acid lyase K164 mutant complexed with N-Acetylneuraminic acid==
[[http://www.uniprot.org/uniprot/NANA_PASMU NANA_PASMU]] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity).  
<StructureSection load='4imf' size='340' side='right'caption='[[4imf]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4imf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pasteurella_multocida_subsp._gallicida_P1059 Pasteurella multocida subsp. gallicida P1059]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ME2:1-ETHOXY-2-(2-METHOXYETHOXY)ETHANE'>ME2</scene>, <scene name='pdbligand=SI3:5-(ACETYLAMINO)-3,5-DIDEOXY-D-GLYCERO-D-GALACTO-NON-2-ULOSONIC+ACID'>SI3</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4imf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imf OCA], [https://pdbe.org/4imf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4imf RCSB], [https://www.ebi.ac.uk/pdbsum/4imf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4imf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NANA_PASMU NANA_PASMU] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity).


==About this Structure==
==See Also==
[[4imf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pasteurella_multocida_subsp._gallicida_p1059 Pasteurella multocida subsp. gallicida p1059]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMF OCA].
*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:024152047</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: N-acetylneuraminate lyase]]
[[Category: Pasteurella multocida subsp. gallicida P1059]]
[[Category: Pasteurella multocida subsp. gallicida p1059]]
[[Category: Fisher AJ]]
[[Category: Fisher, A J.]]
[[Category: Huynh N]]
[[Category: Huynh, N.]]
[[Category: Lyase]]
[[Category: Schiff base]]
[[Category: Tim barrel]]
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