4nej: Difference between revisions
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New page: '''Unreleased structure''' The entry 4nej is ON HOLD Authors: Brenke, R., Jehle, S, Vajda, S., Allen, K.N., Kozakov, D. Description: Small molecular fragment bound to crystal contact i... |
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==Small molecular fragment bound to crystal contact interface of Interleukin-2== | |||
<StructureSection load='4nej' size='340' side='right'caption='[[4nej]], [[Resolution|resolution]] 1.92Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4nej]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NEJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.919Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2K1:5-METHYLFURAN-2-CARBOXYLIC+ACID'>2K1</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nej OCA], [https://pdbe.org/4nej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nej RCSB], [https://www.ebi.ac.uk/pdbsum/4nej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nej ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | |||
==See Also== | |||
*[[Interleukin 3D structures|Interleukin 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Allen KN]] | |||
[[Category: Brenke R]] | |||
[[Category: Jehle S]] | |||
[[Category: Kozakov D]] | |||
[[Category: Vajda S]] | |||
Latest revision as of 03:18, 21 November 2024
Small molecular fragment bound to crystal contact interface of Interleukin-2
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