4nh7: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4nh7 is ~~ON HOLD~~

==Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity==

== Structural highlights ==

<table><tr><td colspan='2'>[[4nh7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NH7 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4NH7 FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E0G:4-[6,6-dimethyl-4-oxidanylidene-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-oxidanylcyclohexyl)amino]benzamide'>E0G</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4nh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nh7 OCA], [https://pdbe.org/4nh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nh7 RCSB], [https://www.ebi.ac.uk/pdbsum/4nh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nh7 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

~~Authors~~: ~~Zuccola, H. J.,~~ Ernst, J.

==See Also==

*[[Heat Shock Protein structures|Heat Shock Protein structures]]

~~Description~~: ~~Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity~~

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Ernst J]]

[[Category: Zuccola HJ]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4nh7 is ON HOLD
+==Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity==
+<StructureSection load='4nh7' size='340' side='right'caption='[[4nh7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4nh7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NH7 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E0G:4-[6,6-dimethyl-4-oxidanylidene-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-oxidanylcyclohexyl)amino]benzamide'>E0G</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nh7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nh7 OCA], [https://pdbe.org/4nh7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nh7 RCSB], [https://www.ebi.ac.uk/pdbsum/4nh7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nh7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
-Authors: Zuccola, H. J., Ernst, J.
+==See Also==
+*[[Heat Shock Protein structures|Heat Shock Protein structures]]
-Description: Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Ernst J]]
+[[Category: Zuccola HJ]]