4my8: Difference between revisions
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== | ==Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor Q21== | ||
[[http://www.uniprot.org/uniprot/ | <StructureSection load='4my8' size='340' side='right'caption='[[4my8]], [[Resolution|resolution]] 2.29Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4my8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._Ames Bacillus anthracis str. Ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MY8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2924Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=Q21:(2S)-2-(NAPHTHALEN-1-YLOXY)-N-[2-(PYRIDIN-4-YL)-1,3-BENZOXAZOL-5-YL]PROPANAMIDE'>Q21</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4my8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4my8 OCA], [https://pdbe.org/4my8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4my8 RCSB], [https://www.ebi.ac.uk/pdbsum/4my8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4my8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A6L8P2U9_BACAN A0A6L8P2U9_BACAN] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] | |||
== | ==See Also== | ||
[[ | *[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Bacillus anthracis str. Ames]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Cuny | [[Category: Anderson WF]] | ||
[[Category: Gorla | [[Category: CSGID]] | ||
[[Category: Gu | [[Category: Cuny G]] | ||
[[Category: Hedstrom | [[Category: Gorla SK]] | ||
[[Category: Joachimiak | [[Category: Gu M]] | ||
[[Category: Kavitha | [[Category: Hedstrom L]] | ||
[[Category: Kim | [[Category: Joachimiak A]] | ||
[[Category: Makowska-Grzyska | [[Category: Kavitha M]] | ||
[[Category: Kim Y]] | |||
[[Category: Makowska-Grzyska M]] | |||
Latest revision as of 16:44, 20 September 2023
Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor Q21
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