2q6m: Difference between revisions

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[[Image:2q6m.jpg|left|200px]]<br /><applet load="2q6m" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2q6m, resolution 1.250&Aring;" />
'''Identification, Characterization and Structure of Cholix toxin from Vibrio cholerae'''<br />


==About this Structure==
==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with the PJ34 inhibitor==
2Q6M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae] with <scene name='pdbligand=P34:'>P34</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AC1:P34+Binding+Site+For+Residue+A+1001'>AC1</scene> and <scene name='pdbsite=AC2:P34+Binding+Site+For+Residue+A+1002'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q6M OCA].  
<StructureSection load='2q6m' size='340' side='right'caption='[[2q6m]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
[[Category: Single protein]]
== Structural highlights ==
<table><tr><td colspan='2'>[[2q6m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q6M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P34:N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE'>P34</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q6m OCA], [https://pdbe.org/2q6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q6m RCSB], [https://www.ebi.ac.uk/pdbsum/2q6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q6m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>
 
==See Also==
*[[Exotoxin 3D structures|Exotoxin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Vibrio cholerae]]
[[Category: Vibrio cholerae]]
[[Category: Jorgensen, R.]]
[[Category: Jorgensen R]]
[[Category: Merrill, A R.]]
[[Category: Merrill AR]]
[[Category: P34]]
[[Category: alpha-beta complex]]
[[Category: domain iii (c-terminal catalytic domain)]]
[[Category: toxin]]
 
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Retrieved from "https://proteopedia.org/2q6m"