BAG protein: Difference between revisions

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<StructureSection load='3fzf' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (grey) and ATP (PDB entry [[3fzf]])' scene=''>
<StructureSection load='' size='350' side='right' caption='Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (magenta) and ATP (PDB entry [[3fzf]])' scene='56/568986/Cv/1'>
 
== Function ==
      
      
The '''BAG family proteins ('''Bcl-2 associated athanogenes) perform diverse functions. They contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.  '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function.
The '''BAG family proteins''' ('''Bcl-2 associated athanogenes''') or '''BAG-family molecular chaperone protein''' perform diverse functions. '''BAG-1, BAG-2, BAG-4, BAG-5''' or '''BAG family molecular chaperone regulator''' inhibit the chaperone function of HSC70 and have anti-apoptotic function. <ref>PMID:18264803</ref>
 
==3D structures of BAG family proteins==


'''BAG-1'''
== Structural highlights ==


[[1i6z]] – mBAG-1 BAG domain - mouse<br />
BAG proteins contain a common BAG domain ca. 45 amino acid long near the C terminal which is conserved.
[[2lwp]] – mBAG-1 BAG domain - NMR<br />
[[1t7s]] – BAG-1 BAG domain – Caenorhabditis elegans<br />
[[4hwc]] – AtBAG-1 BAG domain – Arabidopsis thaliana<br />
[[1wxv]] – hBAG-1 BAG domain – human - NMR<br />


'''BAG-1 complex with HSC70'''
==3D structures of BAG family proteins==
 
[[BAG family proteins 3D structures]]
[[3fzf]] – hBAG-1 BAG domain + HSC70 ATPase domain + ATP<br />
[[3fzh]], [[3fzk]],  [[3fzl]], [[3fzm]], [[3ldq]], [[3m3z]] – hBAG-1 BAG domain + HSC70 ATPase domain + inhibitor<br />
[[4hwi]] – AtBAG-1 BAG domain + HSC70 ATPase domain <br />
[[1hx1]] – BAG-1 BAG domain + HSC70 ATPase domain - bovine<br />
 
'''BAG-2'''
 
[[3d0t]] – mBAG-2 BAG domain <br />
 
 
'''BAG-2 complex with HSC70'''
 
[[3cqx]] – mBAG-2 BAG domain + HSC70 ATPase domain <br />
 
'''BAG-4'''
 
[[1m62]], [[1m7k]] – hBAG-4 BAG domain - NMR<br />
 
'''BAG-5'''
 
[[1ugo]] – mBAG-5 BAG domain - NMR<br />
[[2d9d]] – hBAG-5 BAG domain - NMR<br />


'''BAG-5 complex with HSC70'''
</StructureSection>


[[3a8y]] – hBAG-5 BAG domain + HSC70 ATPase domain <br />
== References ==
<references/>
[[Category: Topic Page]]

Latest revision as of 08:45, 2 May 2020

Structure of human BAG-1 BAG domain (green) complex with HSC70 ATPase domain (magenta) and ATP (PDB entry 3fzf)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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