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[[Image:2qme.gif|left|200px]]<br /><applet load="2qme" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2qme, resolution 1.75&Aring;" />
'''Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)'''<br />


==About this Structure==
==Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)==
2QME is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=GCP:'>GCP</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QME OCA].  
<StructureSection load='2qme' size='340' side='right'caption='[[2qme]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2qme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QME FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qme OCA], [https://pdbe.org/2qme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qme RCSB], [https://www.ebi.ac.uk/pdbsum/2qme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qme ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qm/2qme_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qme ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Rac 3D structures|Rac 3D structures]]
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Bunkoczi G]]
[[Category: Bunkoczi, G.]]
[[Category: Burgess-Brown N]]
[[Category: Burgess-Brown, N.]]
[[Category: Doyle D]]
[[Category: Delft, F von.]]
[[Category: Edwards A]]
[[Category: Doyle, D.]]
[[Category: Elkins JM]]
[[Category: Edwards, A.]]
[[Category: Knapp S]]
[[Category: Elkins, J M.]]
[[Category: Sundstrom M]]
[[Category: Knapp, S.]]
[[Category: Ugochukwu E]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weigelt J]]
[[Category: Sundstrom, M.]]
[[Category: Yang X]]
[[Category: Ugochukwu, E.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: Yang, X.]]
[[Category: GCP]]
[[Category: GOL]]
[[Category: MG]]
[[Category: allosteric enzyme]]
[[Category: alternative splicing]]
[[Category: apoptosis]]
[[Category: atp-binding]]
[[Category: cell junction]]
[[Category: cell projection]]
[[Category: crib]]
[[Category: cytoplasm]]
[[Category: gtp-binding]]
[[Category: gtpase rac3]]
[[Category: kinase]]
[[Category: lipoprotein]]
[[Category: membrane]]
[[Category: methylation]]
[[Category: nucleotide-binding]]
[[Category: p21 rac]]
[[Category: phosphorylation]]
[[Category: prenylation]]
[[Category: ras-related c3 botulinum toxin substrate 3]]
[[Category: serine/threonine-protein kinase]]
[[Category: sgc]]
[[Category: signaling protein]]
[[Category: signaling protein/transferase complex]]
[[Category: small gtp binding protein]]
[[Category: structural genomics]]
[[Category: structural genomics consortium]]
[[Category: transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:40:26 2008''
Retrieved from "https://proteopedia.org/2qme"