4guo: Difference between revisions

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~~{{STRUCTURE_4guo| PDB=4guo | SCENE= }}~~

~~===structure of p73 DNA binding domain complex with 12 bp DNA===~~

==~~Function~~==

==structure of p73 DNA binding domain complex with 12 bp DNA==

[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>

== Structural highlights ==

<table><tr><td colspan='2'>[[4guo]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUO OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4GUO FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.19Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4guo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4guo OCA], [https://pdbe.org/4guo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4guo RCSB], [https://www.ebi.ac.uk/pdbsum/4guo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4guo ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>

==~~About this Structure~~==

==See Also==

[[~~4guo~~]] ~~is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUO OCA].~~

*[[P73|P73]]

== References ==

==~~Reference~~==

__TOC__

[[Category: ~~Ethayathulla, A S~~]]

</StructureSection>

[[Category: ~~Viadiu, H.~~]]

[[Category: Homo sapiens]]

[[Category: ~~Beta-immunoglobulin fold~~]]

[[Category: Large Structures]]

[[Category: ~~Dna]]~~

[[Category: Ethayathulla AS]]

~~[[Category: Dna binding]]~~

[[Category: Viadiu H]]

~~[[Category: Transcription factor]]~~

~~[[Category: Transcription-dna complex]]~~

~~[[Category: Tumor suppressor~~]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4guo|  PDB=4guo  |  SCENE=  }}
-===structure of p73 DNA binding domain complex with 12 bp DNA===
-==Function==
+==structure of p73 DNA binding domain complex with 12 bp DNA==
-[[http://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN]] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
+<StructureSection load='4guo' size='340' side='right'caption='[[4guo]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4guo]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GUO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.19&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4guo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4guo OCA], [https://pdbe.org/4guo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4guo RCSB], [https://www.ebi.ac.uk/pdbsum/4guo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4guo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>
-==About this Structure==
+==See Also==
-[[4guo]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUO OCA].
+*[[P73|P73]]
+== References ==
-==Reference==
+<references/>
-<references group="xtra"/><references/>
+__TOC__
-[[Category: Ethayathulla, A S]]
+</StructureSection>
-[[Category: Viadiu, H.]]
+[[Category: Homo sapiens]]
-[[Category: Beta-immunoglobulin fold]]
+[[Category: Large Structures]]
-[[Category: Dna]]
+[[Category: Ethayathulla AS]]
-[[Category: Dna binding]]
+[[Category: Viadiu H]]
-[[Category: Transcription factor]]
-[[Category: Transcription-dna complex]]
-[[Category: Tumor suppressor]]