4i1n: Difference between revisions

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{{STRUCTURE_4i1n|  PDB=4i1n  |  SCENE=  }}
===R104A-ca1697 nanobody binding to the binary DHFR.folate complex===


==Function==
==R104A-ca1697 nanobody binding to the binary DHFR.folate complex==
[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.  
<StructureSection load='4i1n' size='340' side='right'caption='[[4i1n]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4i1n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.888&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1n OCA], [https://pdbe.org/4i1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1n RCSB], [https://www.ebi.ac.uk/pdbsum/4i1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.


==About this Structure==
==See Also==
[[4i1n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1N OCA].
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
[[Category: Dihydrofolate reductase]]
__TOC__
[[Category: Barlow, J N.]]
</StructureSection>
[[Category: Oyen, D.]]
[[Category: Escherichia coli K-12]]
[[Category: Steyaert, J.]]
[[Category: Lama glama]]
[[Category: Alpha/beta fold]]
[[Category: Large Structures]]
[[Category: Folate derivative]]
[[Category: Barlow JN]]
[[Category: Hydride transfer]]
[[Category: Oyen D]]
[[Category: Immunoglobulin fold]]
[[Category: Steyaert J]]
[[Category: Nadph]]
[[Category: Oxidoreductase-immune system complex]]
[[Category: Reductase]]

Latest revision as of 10:05, 30 October 2024

R104A-ca1697 nanobody binding to the binary DHFR.folate complex

4i1n, resolution 1.89Å

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