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[[Image:2qpy.jpg|left|200px]]<br /><applet load="2qpy" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2qpy, resolution 2.5&Aring;" />
'''AR LBD with small molecule'''<br />


==About this Structure==
==AR LBD with small molecule==
2QPY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=DHT:'>DHT</scene> and <scene name='pdbligand=4HY:'>4HY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QPY OCA].  
<StructureSection load='2qpy' size='340' side='right'caption='[[2qpy]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2qpy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QPY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QPY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HY:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC+ACID'>4HY</scene>, <scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qpy OCA], [https://pdbe.org/2qpy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qpy RCSB], [https://www.ebi.ac.uk/pdbsum/2qpy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qpy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANDR_MOUSE ANDR_MOUSE] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qp/2qpy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qpy ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Androgen receptor 3D structures|Androgen receptor 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Synthetic construct]]
[[Category: Estebanez-Perpina, E.]]
[[Category: Estebanez-Perpina E]]
[[Category: Fletterick, R.]]
[[Category: Fletterick R]]
[[Category: 4HY]]
[[Category: DHT]]
[[Category: androgen receptor dht coactivator]]
[[Category: dna binding protein]]
[[Category: dna-binding]]
[[Category: lipid-binding]]
[[Category: metal-binding]]
[[Category: nucleus]]
[[Category: steroid-binding]]
[[Category: transcription]]
[[Category: transcription regulation]]
[[Category: ubl conjugation]]
[[Category: zinc]]
[[Category: zinc-finger]]
 
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Retrieved from "https://proteopedia.org/2qpy"