2qu4: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(14 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2qu4.jpg|left|200px]]<br /><applet load="2qu4" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2qu4" />
'''Model for Bacterial ParM Filament'''<br />


==Overview==
==Model for Bacterial ParM Filament==
Bacterial ParM is a homolog of eukaryotic actin and is involved in moving plasmids so that they segregate properly during cell division. Using cryo-EM and three-dimensional reconstruction, we show that ParM filaments have a different structure from F-actin, with very different subunit-subunit interfaces. These interfaces result in the helical handedness of the ParM filament being opposite to that of F-actin. Like F-actin, ParM filaments have a variable twist, and we show that this involves domain-domain rotations within the ParM subunit. The present results yield new insights into polymorphisms within F-actin, as well as the evolution of polymer families.
<SX load='2qu4' size='340' side='right' viewer='molstar' caption='[[2qu4]], [[Resolution|resolution]] 16.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2qu4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QU4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 16&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qu4 OCA], [https://pdbe.org/2qu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qu4 RCSB], [https://www.ebi.ac.uk/pdbsum/2qu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qu4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PARM_ECOLX PARM_ECOLX] Involved in the control of plasmid partition. Required for the accurate segregation of the plasmid.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qu/2qu4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qu4 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2QU4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QU4 OCA].
*[[Plasmid segregation protein ParM|Plasmid segregation protein ParM]]
 
__TOC__
==Reference==
</SX>
The structure of bacterial ParM filaments., Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH, Nat Struct Mol Biol. 2007 Oct;14(10):921-6. Epub 2007 Sep 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17873883 17873883]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Egelman, E H.]]
[[Category: Egelman EH]]
[[Category: Galkin, V E.]]
[[Category: Galkin VE]]
[[Category: Garner, E C.]]
[[Category: Garner EC]]
[[Category: Heuser, J.]]
[[Category: Heuser J]]
[[Category: Mullins, R D.]]
[[Category: Mullins RD]]
[[Category: Orlova, A.]]
[[Category: Orlova A]]
[[Category: actin-like protein]]
[[Category: filament model]]
[[Category: helical polymer]]
[[Category: plasmid]]
[[Category: plasmid partition]]
[[Category: structural protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:42:15 2008''
Retrieved from "https://proteopedia.org/2qu4"