Complexin: Difference between revisions

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~~{{STRUCTURE_3rk3| PDB~~=3rk3 ~~| SIZE~~=~~400| SCENE~~= |right~~|CAPTION~~=Human complexin (magenta) as part of the SNARE complex (VAMP2 - ~~grey~~; syntaxin - green; SNAP25 (pink and yellow), [[3rk3]] }}

== Function ==

'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of ~~vescicle~~ fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent ~~vescicle~~ fusion while in another conformation it releases the SNARE complex allowing fusion.

'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity. CPLX acts as both inhibitor and facilitator of vesicle fusion and neurotransmitter release at the synapse. CPLX clamps SNARE complexes to prevent vesicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:12200427</ref>

~~{{TOC limit|limit~~=~~2}}~~

== Structural highlights ==

<scene name='46/466533/Cv/2'>CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin</scene> (PDB entry [[3rk3]]).<ref>PMID:21785414</ref>

</StructureSection>

==3D structures of complexin==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

[[1kil]] – ~~CPLX~~ + ~~SNARE~~ – rat

[[3rk3]], [[3rl0]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human<br />

[[1kil]] – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat<br />

[[~~3rk3~~]], [[~~3rl0~~]] - ~~CPLX~~ + ~~SNARE – human~~

[[5w5c]], [[5w5d]] - rCPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin <br />

== References ==

[[Category:Topic Page]]

Complexin: Difference between revisions

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+<StructureSection load='3rk3' size='350' side='right' caption='Human complexin (magenta) as part of the SNARE complex (VAMP2 - cyan; syntaxin - green; SNAP25 (pink and yellow) (PDB entry [[3rk3]])' scene='46/466533/Cv/1'>
-{{STRUCTURE_3rk3|  PDB=3rk3  | SIZE=400| SCENE= |right|CAPTION=Human complexin (magenta) as part of the SNARE complex (VAMP2 - grey; syntaxin - green; SNAP25 (pink and yellow), [[3rk3]] }}
+== Function ==
-'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity.  CPLX acts as both inhibitor and facilitator of vescicle fusion and neurotransmitter release at the synapse.  CPLX clamps SNARE complexes to prevent vescicle fusion while in another conformation it releases the SNARE complex allowing fusion.
+'''Complexin''' (CPLX) is the protein which binds the SNARE protein complex with high affinity.  CPLX acts as both inhibitor and facilitator of vesicle fusion and neurotransmitter release at the synapse.  CPLX clamps SNARE complexes to prevent vesicle fusion while in another conformation it releases the SNARE complex allowing fusion.<ref>PMID:12200427</ref>
-{{TOC limit|limit=2}}
+== Structural highlights ==
+<scene name='46/466533/Cv/2'>CPLX binds to v-SNARE protein VAMP2 and to t-SNARE proteins SNAP25 and syntaxin</scene> (PDB entry [[3rk3]]).<ref>PMID:21785414</ref>
+</StructureSection>
 ==3D structures of complexin==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-[[1kil]] – CPLX + SNARE – rat
+[[3rk3]], [[3rl0]] - CPLX + Vamp2 + Syntaxin 1A + Snap25 – human<br />
+[[1kil]] – rCPLX + Vamp2 + Syntaxin 1A + Snap25 – rat<br />
-[[3rk3]], [[3rl0]] - CPLX + SNARE – human
+[[5w5c]], [[5w5d]] - rCPLX + Vamp2 + Syntaxin 1A + Snap25 + synaptotagmin <br />
+== References ==
+<references/>
 [[Category:Topic Page]]