Sandbox Reserved 765: Difference between revisions
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All of the beta sheets within each monomer run anti-parallel with one another. Helices are divided into two categories: alpha helices and 3/10 helices. In the structure there are eleven alpha helices and | All of the beta sheets within each monomer run anti-parallel with one another. Helices are divided into two categories: alpha helices and 3/10 helices. In the structure there are eleven alpha helices and | ||
there are six 3/10 helices. The image to the right displays the sequence of chorismate synthase. We can examine the two structures, <scene name='56/564041/Unbound_chorismate_synthase/1'>unbound</scene> chorismate synthase and with mycobacterium tuberculosis <scene name='56/564041/Bound_chorismate_synthase/1'>bound</scene> and FMN bound. The <scene name='56/564041/N-c_terminal/1'>N and C terminus</scene> are both present within each monomer and goes from blue to red. | there are six 3/10 helices. The image to the right displays the sequence of chorismate synthase. We can examine the two structures, <scene name='56/564041/Unbound_chorismate_synthase/1'>unbound</scene> chorismate synthase and with ''mycobacterium tuberculosis'' <scene name='56/564041/Bound_chorismate_synthase/1'>bound</scene> and FMN bound. The <scene name='56/564041/N-c_terminal/1'>N and C terminus</scene> are both present within each monomer and goes from blue to red. | ||
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==Implications== | ==Implications== | ||
The implications with studying choristmate synthase revolves around the fact that it isn not present in humans but is essential for bacteria, plants and parasites. This pathway gives rise to many potential antimicrobial drugs which decreases possible negative impacts of drugs in humans <ref>PMID:4550759</ref>. | Enzymes present in the shikimate pathway are important in microorganism survival. The enzymes of the shikimate pathway are a great source for antimicrobial agents, herbicides, inhibitors and drugs. The implications with studying choristmate synthase revolves around the fact that it isn not present in humans but is essential for bacteria, plants and parasites. This pathway gives rise to many potential antimicrobial drugs which decreases possible negative impacts of drugs in humans <ref>PMID:4550759</ref>. One major disease is ''mycobacterium tuberculosis'', that can be stopped using chemotherapy due to the use of inhibitors that can prevent chorismate to be produced and effect the human body. | ||
</StructureSection> | |||
==References== | |||
{{reflist}} | |||
