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{{STRUCTURE_4jrk|  PDB=4jrk  |  SCENE=  }}
===Crystal Structure of Escherichia coli Hfq Surface Mutant===
{{ABSTRACT_PUBMED_24288369}}


==Function==
==Crystal Structure of Escherichia coli Hfq Surface Mutant==
[[http://www.uniprot.org/uniprot/HFQ_ECOLI HFQ_ECOLI]] RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32. Binds with high specificity to tRNAs. In vitro, stimulates synthesis of long tails by poly(A) polymerase I. Required for RNA phage Qbeta replication.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref>  Seems to play a role in persister cell formation; upon overexpression decreases persister cell formation while deletion increases persister formation.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref>
<StructureSection load='4jrk' size='340' side='right'caption='[[4jrk]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jrk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JRK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.894&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jrk OCA], [https://pdbe.org/4jrk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jrk RCSB], [https://www.ebi.ac.uk/pdbsum/4jrk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jrk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HFQ_ECOLI HFQ_ECOLI] RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Involved in the regulation of stress responses mediated by the sigma factors RpoS, sigma-E and sigma-32. Binds with high specificity to tRNAs. In vitro, stimulates synthesis of long tails by poly(A) polymerase I. Required for RNA phage Qbeta replication.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref>  Seems to play a role in persister cell formation; upon overexpression decreases persister cell formation while deletion increases persister formation.<ref>PMID:805130</ref> <ref>PMID:10677490</ref> <ref>PMID:11222598</ref> <ref>PMID:17158661</ref> <ref>PMID:19909729</ref>  


==About this Structure==
==See Also==
[[4jrk]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JRK OCA].
*[[Protein Hfq 3D structures|Protein Hfq 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:024288369</ref><references group="xtra"/><references/>
__TOC__
[[Category: Orans, J.]]
</StructureSection>
[[Category: Robinson, K E.]]
[[Category: Escherichia coli K-12]]
[[Category: Post-transcriptional regulator]]
[[Category: Large Structures]]
[[Category: Riboregulator]]
[[Category: Orans J]]
[[Category: Rna binding protein]]
[[Category: Robinson KE]]
Retrieved from "https://proteopedia.org/4jrk"