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{{STRUCTURE_4nt0|  PDB=4nt0  |  SCENE=  }}
===Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 3-deazauridine 5'-monophosphate===


==Function==
==Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 3-deazauridine 5'-monophosphate==
[[http://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]  
<StructureSection load='4nt0' size='340' side='right'caption='[[4nt0]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4nt0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NT0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.769&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DU:4-HYDROXY-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)PYRIDIN-2(1H)-ONE'>3DU</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nt0 OCA], [https://pdbe.org/4nt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nt0 RCSB], [https://www.ebi.ac.uk/pdbsum/4nt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nt0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]


==About this Structure==
==See Also==
[[4nt0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NT0 OCA].
*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
__TOC__
[[Category: Almo, S C.]]
</StructureSection>
[[Category: Fedorov, A A.]]
[[Category: Large Structures]]
[[Category: Fedorov, E V.]]
[[Category: Methanothermobacter thermautotrophicus]]
[[Category: Gerlt, J A.]]
[[Category: Almo SC]]
[[Category: Iiams, V.]]
[[Category: Fedorov AA]]
[[Category: 3-deazauridine 5'-monophosphate]]
[[Category: Fedorov EV]]
[[Category: Lyase]]
[[Category: Gerlt JA]]
[[Category: Orotidine 5'-monophosphate decarboxylase]]
[[Category: Iiams V]]
[[Category: Tim-barrel]]

Latest revision as of 17:03, 20 September 2023

Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with 3-deazauridine 5'-monophosphate

4nt0, resolution 1.77Å

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