4o38: Difference between revisions
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==Crystal structure of the human cyclin G associated kinase (GAK)== | |||
<StructureSection load='4o38' size='340' side='right'caption='[[4o38]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4o38]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ll6 3ll6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O38 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o38 OCA], [https://pdbe.org/4o38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o38 RCSB], [https://www.ebi.ac.uk/pdbsum/4o38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o38 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GAK_HUMAN GAK_HUMAN] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.<ref>PMID:10625686</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Chaikuad A]] | |||
[[Category: Edwards A]] | |||
[[Category: Eswaran J]] | |||
[[Category: Fedorov O]] | |||
[[Category: Hatzos-Skintges C]] | |||
[[Category: Joachimiak A]] | |||
[[Category: King O]] | |||
[[Category: Knapp S]] | |||
[[Category: Weger A]] | |||
[[Category: Weigelt J]] | |||
[[Category: Zhang R]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 08:54, 18 January 2023
Crystal structure of the human cyclin G associated kinase (GAK)
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