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{{STRUCTURE_2mgv|  PDB=2mgv  |  SCENE=  }}
===NMR structure of PASTA domain of PonA2 from Mycobacterium tuberculosis===
{{ABSTRACT_PUBMED_24281824}}


==About this Structure==
==NMR structure of PASTA domain of PonA2 from Mycobacterium tuberculosis==
[[2mgv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGV OCA].  
<StructureSection load='2mgv' size='340' side='right'caption='[[2mgv]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mgv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MGV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgv OCA], [https://pdbe.org/2mgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mgv RCSB], [https://www.ebi.ac.uk/pdbsum/2mgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mgv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/I6YGX2_MYCTU I6YGX2_MYCTU]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
PonA2 is one of the two class A Penicillin binding proteins of Mycobacterium tuberculosis, the etiologic agent of tuberculosis. It plays a complex role in mycobacterial physiology and is spotted as a promising target for inhibitors. PonA2 is involved in adaptation of M. tuberculosis to dormancy, an ability which has been attributed to the presence in its sequence of a C-terminal PASTA domain. Since PASTA modules are typically considered as beta-lactam antibiotic binding domains, we determined the solution structure of the PASTA domain from PonA2 and analysed its binding properties versus a plethora of potential binders, including the beta-lactam antibiotics, two typical muropeptide mimics and polymeric peptidoglycan. We show that, despite a high structural similarity with other PASTA domains, the PASTA domain of PonA2 displays different binding properties, as it is not able to bind muropeptides, nor beta-lactams, nor polymeric peptidoglycan. These results indicate that the role of PASTA domains cannot be generalized, as their specific binding properties strongly depend on surface residues, which are widely variable.


==Reference==
Structural and binding properties of the PASTA domain of PonA2, a key penicillin binding protein from Mycobacterium tuberculosis.,Calvanese L, Falcigno L, Maglione C, Marasco D, Ruggiero A, Squeglia F, Berisio R, D'Auria G Biopolymers. 2013 Nov 27. doi: 10.1002/bip.22447. PMID:24281824<ref>PMID:24281824</ref>
<ref group="xtra">PMID:024281824</ref><references group="xtra"/><references/>
 
[[Category: Auria, G D.]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Berisio, R.]]
</div>
[[Category: Calvanese, L.]]
<div class="pdbe-citations 2mgv" style="background-color:#fffaf0;"></div>
[[Category: Falcigno, L.]]
== References ==
[[Category: Maglione, C.]]
<references/>
[[Category: Marasco, D.]]
__TOC__
[[Category: Ruggiero, A.]]
</StructureSection>
[[Category: Squeglia, F.]]
[[Category: Large Structures]]
[[Category: Pasta domain]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Penicillin binding protein]]
[[Category: Berisio R]]
[[Category: Calvanese L]]
[[Category: D'Auria G]]
[[Category: Falcigno L]]
[[Category: Maglione C]]
[[Category: Marasco D]]
[[Category: Ruggiero A]]
[[Category: Squeglia F]]
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