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{{STRUCTURE_4o38|  PDB=4o38  |  SCENE=  }}
===Crystal structure of the human cyclin G associated kinase (GAK)===


==Function==
==Crystal structure of the human cyclin G associated kinase (GAK)==
[[http://www.uniprot.org/uniprot/GAK_HUMAN GAK_HUMAN]] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.<ref>PMID:10625686</ref> 
<StructureSection load='4o38' size='340' side='right'caption='[[4o38]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4o38]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ll6 3ll6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O38 FirstGlance]. <br>
[[4o38]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ll6 3ll6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O38 OCA].  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o38 OCA], [https://pdbe.org/4o38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o38 RCSB], [https://www.ebi.ac.uk/pdbsum/4o38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o38 ProSAT]</span></td></tr>
==Reference==
</table>
<references group="xtra"/><references/>
== Function ==
[[Category: Non-specific serine/threonine protein kinase]]
[https://www.uniprot.org/uniprot/GAK_HUMAN GAK_HUMAN] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.<ref>PMID:10625686</ref>
[[Category: Arrowsmith, C H.]]
== References ==
[[Category: Bountra, C.]]
<references/>
[[Category: Chaikuad, A.]]
__TOC__
[[Category: Delft, F von.]]
</StructureSection>
[[Category: Edwards, A.]]
[[Category: Homo sapiens]]
[[Category: Eswaran, J.]]
[[Category: Large Structures]]
[[Category: Fedorov, O.]]
[[Category: Arrowsmith CH]]
[[Category: Hatzos-Skintges, C.]]
[[Category: Bountra C]]
[[Category: Joachimiak, A.]]
[[Category: Chaikuad A]]
[[Category: King, O.]]
[[Category: Edwards A]]
[[Category: Knapp, S.]]
[[Category: Eswaran J]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Fedorov O]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Hatzos-Skintges C]]
[[Category: Weger, A.]]
[[Category: Joachimiak A]]
[[Category: Weigelt, J.]]
[[Category: King O]]
[[Category: Zhang, R.]]
[[Category: Knapp S]]
[[Category: Atp-binding]]
[[Category: Weger A]]
[[Category: Cell cycle]]
[[Category: Weigelt J]]
[[Category: Cell junction]]
[[Category: Zhang R]]
[[Category: Clathrine]]
[[Category: Von Delft F]]
[[Category: Cyclin g]]
[[Category: Golgi apparatus]]
[[Category: Kinase]]
[[Category: Mcsg]]
[[Category: Membrane trafficking]]
[[Category: Midwest center for structural genomic]]
[[Category: Nucleotide-binding]]
[[Category: P53]]
[[Category: Phosphoprotein]]
[[Category: Protein kinase]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Serine/threonine kinase]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]

Latest revision as of 08:54, 18 January 2023

Crystal structure of the human cyclin G associated kinase (GAK)

4o38, resolution 2.10Å

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