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{{STRUCTURE_4ley|  PDB=4ley  |  SCENE=  }}
===Structure of mouse cGAS bound to 18 bp DNA===
{{ABSTRACT_PUBMED_24332030}}


==Function==
==Structure of mouse cGAS bound to 18 bp DNA==
[[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.  
<StructureSection load='4ley' size='340' side='right'caption='[[4ley]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ley]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LEY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ley FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ley OCA], [https://pdbe.org/4ley PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ley RCSB], [https://www.ebi.ac.uk/pdbsum/4ley PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ley ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.


==About this Structure==
==See Also==
[[4ley]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEY OCA].
*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:024332030</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Li, P.]]
[[Category: Mus musculus]]
[[Category: Dna sensor]]
[[Category: Li P]]
[[Category: Ntase]]
[[Category: Transferase-dna complex]]
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