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{{STRUCTURE_4ce4|  PDB=4ce4  |  SCENE=  }}
===39S large subunit of the porcine mitochondrial ribosome===
{{ABSTRACT_PUBMED_24362565}}


==About this Structure==
==39S large subunit of the porcine mitochondrial ribosome==
[[4ce4]] is a 37 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa_domestica Sus scrofa domestica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CE4 OCA].  
<SX load='4ce4' size='340' side='right' viewer='molstar' caption='[[4ce4]], [[Resolution|resolution]] 4.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ce4]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa_domesticus Sus scrofa domesticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CE4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N:ANY+5-MONOPHOSPHATE+NUCLEOTIDE'>N</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ce4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ce4 OCA], [https://pdbe.org/4ce4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ce4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ce4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ce4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/F1RT79_PIG F1RT79_PIG]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Mitochondrial ribosomes synthesize a number of highly hydrophobic proteins encoded on the genome of mitochondria, the organelles in eukaryotic cells that are responsible for energy conversion by oxidative phosphorylation. The ribosomes in mammalian mitochondria have undergone massive structural changes throughout their evolution, including ribosomal RNA shortening and acquisition of mitochondria-specific ribosomal proteins. Here we present the three-dimensional structure of the 39S large subunit of the porcine mitochondrial ribosome determined by cryo-electron microscopy at 4.9 A resolution. The structure, combined with data from chemical crosslinking and mass spectrometry experiments, reveals the unique features of the 39S subunit at near-atomic resolution and provides detailed insight into the architecture of the polypeptide exit site. This region of the mitochondrial ribosome has been considerably remodelled compared to its bacterial counterpart, providing a specialized platform for the synthesis and membrane insertion of the highly hydrophobic protein components of the respiratory chain.
 
Architecture of the large subunit of the mammalian mitochondrial ribosome.,Greber BJ, Boehringer D, Leitner A, Bieri P, Voigts-Hoffmann F, Erzberger JP, Leibundgut M, Aebersold R, Ban N Nature. 2013 Dec 22. doi: 10.1038/nature12890. PMID:24362565<ref>PMID:24362565</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ce4" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Ribosome|Ribosome]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:024362565</ref><references group="xtra"/><references/>
__TOC__
[[Category: Sus scrofa domestica]]
</SX>
[[Category: Aebersold, R.]]
[[Category: Large Structures]]
[[Category: Ban, N.]]
[[Category: Sus scrofa domesticus]]
[[Category: Bieri, P.]]
[[Category: Aebersold R]]
[[Category: Boehringer, D.]]
[[Category: Ban N]]
[[Category: Erzberger, J P.]]
[[Category: Bieri P]]
[[Category: Greber, B J.]]
[[Category: Boehringer D]]
[[Category: Leibundgut, M.]]
[[Category: Erzberger JP]]
[[Category: Leitner, A.]]
[[Category: Greber BJ]]
[[Category: Voigts-Hoffmann, F.]]
[[Category: Leibundgut M]]
[[Category: 39s large ribosomal subunit]]
[[Category: Leitner A]]
[[Category: Mammalian mitochondrial ribosome]]
[[Category: Voigts-Hoffmann F]]
[[Category: Membrane association]]
[[Category: Polypeptide exit site]]
[[Category: Ribosomal protein]]
[[Category: Ribosome]]
[[Category: Rrna]]
[[Category: Translation]]
Retrieved from "https://proteopedia.org/4ce4"