2miu: Difference between revisions
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New page: '''Unreleased structure''' The entry 2miu is ON HOLD Authors: Yang, Y., Sun, Y., Medrano, E.E., Yian, X., Weiss, M.A. Description: Structure of FHL2 LIM adaptor and its Interaction wit... |
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==Structure of FHL2 LIM adaptor and its Interaction with Ski== | |||
<StructureSection load='2miu' size='340' side='right'caption='[[2miu]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2miu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2miu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miu OCA], [https://pdbe.org/2miu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2miu RCSB], [https://www.ebi.ac.uk/pdbsum/2miu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2miu ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FHL2_HUMAN FHL2_HUMAN] May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.<ref>PMID:15692560</ref> <ref>PMID:16652157</ref> <ref>PMID:18853468</ref> | |||
==See Also== | |||
*[[Muscle LIM protein|Muscle LIM protein]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Medrano EE]] | |||
[[Category: Sun Y]] | |||
[[Category: Tian X]] | |||
[[Category: Weiss MA]] | |||
[[Category: Yang Y]] | |||
Latest revision as of 06:06, 15 May 2024
Structure of FHL2 LIM adaptor and its Interaction with Ski
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