4o8s: Difference between revisions
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New page: '''Unreleased structure''' The entry 4o8s is ON HOLD Authors: Zhao, Y.H., Su, Y.T., Sun, L.F. Description: Crystal structure of JHP933 from Helicobacter pylori |
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==Crystal structure of JHP933 from Helicobacter pylori== | |||
<StructureSection load='4o8s' size='340' side='right'caption='[[4o8s]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4o8s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_J99 Helicobacter pylori J99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O8S FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o8s OCA], [https://pdbe.org/4o8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o8s RCSB], [https://www.ebi.ac.uk/pdbsum/4o8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o8s ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q9ZKK2_HELPJ Q9ZKK2_HELPJ] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Helicobacter pylori is a well-known pathogen involved in the development of peptic ulcer, gastric adenocarcinoma and other forms of gastric cancer. Recently, there has been more considerable interest in strain-specific genes located in plasticity regions with great genetic variability. However, little is known about many of these genes. Studies suggested that certain genes in this region may play key roles in the pathogenesis of H. pylori-associated gastroduodenal diseases. JHP933, a conserved putative protein of unknown function, is encoded by the gene in plasticity region of H. pylori strain J99. Here we have determined the structure of JHP933. Our work demonstrates that JHP933 is a nucleotidyltransferase superfamily protein with a characteristic alphabetaalphabetaalphabetaalpha topology. A superposition demonstrates overall structural homology of the JHP933 N-terminal fragment with lincosamide antibiotic adenylyltransferase LinA and identifies a possible substrate-binding cleft of JHP933. Furthermore, through structural comparison with LinA and LinB, we pinpoint conservative active site residues which may contribute to divalent ion coordination and substrate binding. | |||
Crystal Structure Confirmation of JHP933 as a Nucleotidyltransferase Superfamily Protein from Helicobacter pylori Strain J99.,Zhao Y, Ye X, Su Y, Sun L, She F, Wu Y PLoS One. 2014 Aug 7;9(8):e104609. doi: 10.1371/journal.pone.0104609. eCollection, 2014. PMID:25101777<ref>PMID:25101777</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4o8s" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Helicobacter pylori J99]] | |||
[[Category: Large Structures]] | |||
[[Category: Su YT]] | |||
[[Category: Sun LF]] | |||
[[Category: Wu Y]] | |||
[[Category: Zhao YH]] | |||
Latest revision as of 03:21, 21 November 2024
Crystal structure of JHP933 from Helicobacter pylori
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