3zgh: Difference between revisions
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== | ==Crystal structure of the KRT10-binding region domain of the pneumococcal serine rich repeat protein PsrP== | ||
[[3zgh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGH OCA]. | <StructureSection load='3zgh' size='340' side='right'caption='[[3zgh]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
[[ | == Structural highlights == | ||
[[ | <table><tr><td colspan='2'>[[3zgh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZGH FirstGlance]. <br> | ||
[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgh OCA], [https://pdbe.org/3zgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zgh RCSB], [https://www.ebi.ac.uk/pdbsum/3zgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgh ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PSRP_STRPN PSRP_STRPN] Protein that allows bacteria to adhere to mammalian host cells. Required for full virulence in mouse infection models when infected intranasally (PubMed:16861665). Required for adhesion to host cells in vitro and for persistence in the lower respiratory tract (PubMed:18507531). Binds host keratin 10 (KRT10) on lung cells which mediates adhesion via the C-terminus of the basic region (BR, residues 273-341); glycosylation of either protein is not required for the interaction (PubMed:19627498). A region in the N-terminus (residues 122-166) self aggregates, contributing to mature biofilm formation (PubMed:20714350). The basic region (BR, residues 187-385) also self aggregates; the BR binds DNA which enhances self aggregation (PubMed:27582320).<ref>PMID:16861665</ref> <ref>PMID:18507531</ref> <ref>PMID:19627498</ref> <ref>PMID:20714350</ref> <ref>PMID:27582320</ref> | ||
[[Category: Normark | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Streptococcus pneumoniae TIGR4]] | ||
[[Category: Achour A]] | |||
[[Category: Diamante A]] | |||
[[Category: Ebel C]] | |||
[[Category: Henriques-Normark B]] | |||
[[Category: Hentrich K]] | |||
[[Category: Kikhney A]] | |||
[[Category: Loefling J]] | |||
[[Category: Mikaelsson C]] | |||
[[Category: Normark S]] | |||
[[Category: Schulte T]] | |||
[[Category: Svergun D]] | |||
Latest revision as of 07:12, 1 May 2024
Crystal structure of the KRT10-binding region domain of the pneumococcal serine rich repeat protein PsrP
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