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{{STRUCTURE_3a1y|  PDB=3a1y  |  SCENE=  }}
===The structure of archaeal ribosomal stalk P1/P0 complex===
{{ABSTRACT_PUBMED_20007716}}


==Function==
==The structure of archaeal ribosomal stalk P1/P0 complex==
[[http://www.uniprot.org/uniprot/RL12_PYRHO RL12_PYRHO]] Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. The stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes.<ref>PMID:17804412</ref> [[http://www.uniprot.org/uniprot/RL10_PYRHO RL10_PYRHO]] Forms the large subunit's ribosomal stalk, playing a central role in the interaction of the ribosome with elongation factors; the stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes, although the first site is the most stimulatory.<ref>PMID:17804412</ref>
<StructureSection load='3a1y' size='340' side='right'caption='[[3a1y]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3a1y]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A1Y FirstGlance]. <br>
[[3a1y]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1Y OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a1y OCA], [https://pdbe.org/3a1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a1y RCSB], [https://www.ebi.ac.uk/pdbsum/3a1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a1y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL12_PYRHO RL12_PYRHO] Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. The stalk complex of P.horikoshii binds to E.coli large subunits and confers on them the ability to interact with eukaryotic elongation factors. Each succesive L12 dimer bound along the P0 spine increases the GTPase activity of elongation factors and increases translation by reconsituted ribosomes.<ref>PMID:17804412</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/3a1y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a1y ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ribosomal protein L10|Ribosomal protein L10]]
*[[Ribosomal protein L10|Ribosomal protein L10]]
 
*[[Ribosomal protein P0|Ribosomal protein P0]]
==Reference==
*[[Ribosomal protein P1|Ribosomal protein P1]]
<ref group="xtra">PMID:020007716</ref><references group="xtra"/><references/>
== References ==
[[Category: Pyrococcus shinkaii]]
<references/>
[[Category: Naganuma, T.]]
__TOC__
[[Category: Nomura, N.]]
</StructureSection>
[[Category: Tanaka, I.]]
[[Category: Large Structures]]
[[Category: Uchiumi, T.]]
[[Category: Pyrococcus horikoshii]]
[[Category: Yao, M.]]
[[Category: Naganuma T]]
[[Category: Yu, J.]]
[[Category: Nomura N]]
[[Category: Helix spin]]
[[Category: Tanaka I]]
[[Category: Ribonucleoprotein]]
[[Category: Uchiumi T]]
[[Category: Ribosomal protein]]
[[Category: Yao M]]
[[Category: Stalk]]
[[Category: Yu J]]
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