4o67: Difference between revisions

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'''Unreleased structure'''


The entry 4o67 is ON HOLD
==Human cyclic GMP-AMP synthase (cGAS) in complex with GAMP==
<StructureSection load='4o67' size='340' side='right'caption='[[4o67]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4o67]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O67 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.444&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SY:CGAMP'>1SY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o67 OCA], [https://pdbe.org/4o67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o67 RCSB], [https://www.ebi.ac.uk/pdbsum/4o67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o67 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>


Authors: Zhang, X., Chen, Z., Zhang, X.W., Chen, Z.J.
==See Also==
 
*[[Cyclic GMP-AMP synthase|Cyclic GMP-AMP synthase]]
Description:
*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Chen Z]]
[[Category: Chen ZJ]]
[[Category: Zhang X]]
[[Category: Zhang XW]]
Retrieved from "https://proteopedia.org/4o67"