4nh8: Difference between revisions

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{{STRUCTURE_4nh8|  PDB=4nh8  |  SCENE=  }}
===Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity===
{{ABSTRACT_PUBMED_24332488}}


==Function==
==Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity==
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
<StructureSection load='4nh8' size='340' side='right'caption='[[4nh8]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4nh8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NH8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2LC:2-FLUORO-6-[(3S)-TETRAHYDROFURAN-3-YLAMINO]-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOL-1-YL)BENZAMIDE'>2LC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nh8 OCA], [https://pdbe.org/4nh8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nh8 RCSB], [https://www.ebi.ac.uk/pdbsum/4nh8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nh8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>  


==About this Structure==
==See Also==
[[4nh8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NH8 OCA].
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:024332488</ref><references group="xtra"/><references/>
__TOC__
[[Category: Ernst, J T.]]
</StructureSection>
[[Category: Zuccola, H J.]]
[[Category: Homo sapiens]]
[[Category: A/b protein]]
[[Category: Large Structures]]
[[Category: Chaperone]]
[[Category: Ernst JT]]
[[Category: Zuccola HJ]]
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