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{{STRUCTURE_3ano|  PDB=3ano  |  SCENE=  }}
===Crystal Structure of a Novel Diadenosine 5',5'''-P1,P4-Tetraphosphate Phosphorylase from Mycobacterium tuberculosis H37Rv===
{{ABSTRACT_PUBMED_21565198}}


==Function==
==Crystal Structure of a Novel Diadenosine 5',5'''-P1,P4-Tetraphosphate Phosphorylase from Mycobacterium tuberculosis H37Rv==
[[http://www.uniprot.org/uniprot/AP4A_MYCTU AP4A_MYCTU]] Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.<ref>PMID:19778616</ref> <ref>PMID:21565198</ref>
<StructureSection load='3ano' size='340' side='right'caption='[[3ano]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3ano]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ANO FirstGlance]. <br>
[[3ano]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_sp._h37rv Mycobacterium sp. h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ANO OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.894&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ano FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ano OCA], [https://pdbe.org/3ano PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ano RCSB], [https://www.ebi.ac.uk/pdbsum/3ano PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ano ProSAT]</span></td></tr>
<ref group="xtra">PMID:021565198</ref><references group="xtra"/><references/>
</table>
[[Category: ATP adenylyltransferase]]
== Function ==
[[Category: Mycobacterium sp. h37rv]]
[https://www.uniprot.org/uniprot/AP4A_MYCTU AP4A_MYCTU] Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues.<ref>PMID:19778616</ref> <ref>PMID:21565198</ref>
[[Category: Arakawa, Y.]]
== References ==
[[Category: Mori, S.]]
<references/>
[[Category: Shibayama, K.]]
__TOC__
[[Category: Wachino, J.]]
</StructureSection>
[[Category: Diadenosine polyphosphate]]
[[Category: Large Structures]]
[[Category: Hit motif]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Mycobacterium]]
[[Category: Arakawa Y]]
[[Category: Phosphorylase]]
[[Category: Mori S]]
[[Category: Transferase]]
[[Category: Shibayama K]]
[[Category: Wachino J]]
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