1gtw: Difference between revisions
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== | ==crystal structure of C/EBPbeta bZip homodimer bound to a DNA fragment from the tom-1A promoter== | ||
[[http://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN | <StructureSection load='1gtw' size='340' side='right'caption='[[1gtw]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | |||
== | <table><tr><td colspan='2'>[[1gtw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GTW FirstGlance]. <br> | ||
[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gtw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gtw OCA], [https://pdbe.org/1gtw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gtw RCSB], [https://www.ebi.ac.uk/pdbsum/1gtw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gtw ProSAT]</span></td></tr> | |||
</table> | |||
< | == Function == | ||
[https://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:20829347</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
[[Category: | <jmolCheckbox> | ||
[[Category: | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/1gtw_consurf.spt"</scriptWhenChecked> | ||
[[Category: | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
[[Category: | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gtw ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ogata K]] | |||
[[Category: Tahirov TH]] | |||
Latest revision as of 12:06, 13 December 2023
crystal structure of C/EBPbeta bZip homodimer bound to a DNA fragment from the tom-1A promoter
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