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{{STRUCTURE_3au4|  PDB=3au4  |  SCENE=  }}
===Structure of the human myosin-X MyTH4-FERM cassette bound to its specific cargo, DCC===
{{ABSTRACT_PUBMED_21642953}}


==Disease==
==Structure of the human myosin-X MyTH4-FERM cassette bound to its specific cargo, DCC==
[[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Defects in DCC are the cause of mirror movements type 1 (MRMV1) [MIM:[http://omim.org/entry/157600 157600]]. A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.<ref>PMID:20431009</ref>
<StructureSection load='3au4' size='340' side='right'caption='[[3au4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3au4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AU4 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/MYO10_HUMAN MYO10_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).<ref>PMID:16894163</ref> [[http://www.uniprot.org/uniprot/DCC_HUMAN DCC_HUMAN]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.<ref>PMID:8861902</ref> <ref>PMID:8187090</ref> 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3au4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3au4 OCA], [https://pdbe.org/3au4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3au4 RCSB], [https://www.ebi.ac.uk/pdbsum/3au4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3au4 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[3au4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AU4 OCA].
== Function ==
[https://www.uniprot.org/uniprot/MYO10_HUMAN MYO10_HUMAN] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).<ref>PMID:16894163</ref>  


==See Also==
==See Also==
*[[Myosin|Myosin]]
*[[Myosin 3D Structures|Myosin 3D Structures]]
 
*[[Netrin receptor|Netrin receptor]]
==Reference==
== References ==
<ref group="xtra">PMID:021642953</ref><references group="xtra"/><references/>
<references/>
[[Category: Human]]
__TOC__
[[Category: Hakoshima, T.]]
</StructureSection>
[[Category: Hatano, T.]]
[[Category: Homo sapiens]]
[[Category: Hirano, Y.]]
[[Category: Large Structures]]
[[Category: Motor protein cargo transportation]]
[[Category: Hakoshima T]]
[[Category: Motor protein-apoptosis complex]]
[[Category: Hatano T]]
[[Category: Protein-protein complex]]
[[Category: Hirano Y]]

Latest revision as of 14:02, 13 March 2024

Structure of the human myosin-X MyTH4-FERM cassette bound to its specific cargo, DCC

3au4, resolution 1.90Å

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