2z5z: Difference between revisions

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[[Image:2z5z.jpg|left|200px]]<br /><applet load="2z5z" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2z5z, resolution 3.50&Aring;" />
'''Crystal structure of the complex of buffalo Lactoperoxidase with fluoride ion at 3.5A resolution'''<br />


==About this Structure==
==Crystal structure of the complex of buffalo Lactoperoxidase with fluoride ion at 3.5A resolution==
2Z5Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=IOD:'>IOD</scene>, <scene name='pdbligand=F:'>F</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=OSM:'>OSM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5Z OCA].  
<StructureSection load='2z5z' size='340' side='right'caption='[[2z5z]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2z5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5Z FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OSM:1-(OXIDOSULFANYL)METHANAMINE'>OSM</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5z OCA], [https://pdbe.org/2z5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5z RCSB], [https://www.ebi.ac.uk/pdbsum/2z5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PERL_BUBBU PERL_BUBBU] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.<ref>PMID:12071645</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5z ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Lactoperoxidase|Lactoperoxidase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bubalus bubalis]]
[[Category: Bubalus bubalis]]
[[Category: Peroxidase]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Bhushan A]]
[[Category: Bhushan, A.]]
[[Category: Jain R]]
[[Category: Jain, R.]]
[[Category: Kaur P]]
[[Category: Kaur, P.]]
[[Category: Sharma S]]
[[Category: Sharma, S.]]
[[Category: Sheikh IA]]
[[Category: Sheikh, I A.]]
[[Category: Singh N]]
[[Category: Singh, N.]]
[[Category: Singh TP]]
[[Category: Singh, T P.]]
[[Category: Srinivasan A]]
[[Category: Srinivasan, A.]]
[[Category: CA]]
[[Category: F]]
[[Category: HEM]]
[[Category: IOD]]
[[Category: OSM]]
[[Category: buffalo]]
[[Category: complex]]
[[Category: fluoride]]
[[Category: lactoperoxidase]]
[[Category: oxidoreductase]]
 
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Retrieved from "https://proteopedia.org/2z5z"