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[[Image:2zbt.jpg|left|200px]]<br /><applet load="2zbt" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2zbt, resolution 1.65&Aring;" />
'''Crystal structure of pyridoxine biosynthesis protein from Thermus thermophilus HB8'''<br />


==About this Structure==
==Crystal structure of pyridoxine biosynthesis protein from Thermus thermophilus HB8==
2ZBT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZBT OCA].  
<StructureSection load='2zbt' size='340' side='right'caption='[[2zbt]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
[[Category: Single protein]]
== Structural highlights ==
[[Category: Thermus thermophilus]]
<table><tr><td colspan='2'>[[2zbt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZBT FirstGlance]. <br>
[[Category: Ebihara, A.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
[[Category: Fujimoto, Y.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
[[Category: Kuramitsu, S.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zbt OCA], [https://pdbe.org/2zbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zbt RCSB], [https://www.ebi.ac.uk/pdbsum/2zbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zbt ProSAT], [https://www.topsan.org/Proteins/RSGI/2zbt TOPSAN]</span></td></tr>
[[Category: Manzoku, M.]]
</table>
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
== Function ==
[[Category: Yokoyama, S.]]
[https://www.uniprot.org/uniprot/PDXS_THET8 PDXS_THET8] Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.[HAMAP-Rule:MF_01824]
[[Category: MPD]]
== Evolutionary Conservation ==
[[Category: lyase]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: national project on protein structural and functional analyses]]
Check<jmol>
[[Category: nppsfa]]
  <jmolCheckbox>
[[Category: pyridoxine biosynthesis]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zb/2zbt_consurf.spt"</scriptWhenChecked>
[[Category: riken structural genomics/proteomics initiative]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: rsgi]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: structural genomics]]
  </jmolCheckbox>
 
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zbt ConSurf].
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:01:17 2008''
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus thermophilus HB8]]
[[Category: Ebihara A]]
[[Category: Fujimoto Y]]
[[Category: Kuramitsu S]]
[[Category: Manzoku M]]
[[Category: Yokoyama S]]

Latest revision as of 13:56, 13 March 2024

Crystal structure of pyridoxine biosynthesis protein from Thermus thermophilus HB8

2zbt, resolution 1.65Å

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