3ai8: Difference between revisions

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~~{{STRUCTURE_3ai8| PDB=3ai8 | SCENE= }}~~

~~===Cathepsin B in complex with the nitroxoline===~~

==~~Function~~==

==Cathepsin B in complex with the nitroxoline==

[[~~http://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN~~]] ~~Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis~~.

== Structural highlights ==

==~~About this Structure~~==

<table><tr><td colspan='2'>[[3ai8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AI8 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=3AI8 FirstGlance].

[[3ai8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AI8 OCA].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HNQ:5-NITROQUINOLIN-8-OL'>HNQ</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=3ai8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ai8 OCA], [https://pdbe.org/3ai8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ai8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ai8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ai8 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

==See Also==

*[[Cathepsin|Cathepsin]]

*[[Cathepsin 3D structures|Cathepsin 3D structures]]

~~==Reference==~~

__TOC__

~~<ref group="xtra">PMID:021598397~~</~~ref><references group="xtra"/><references/~~>

</StructureSection>

[[Category: ~~Cathepsin B~~]]

[[Category: Homo sapiens]]

[[Category: ~~Human~~]]

[[Category: Large Structures]]

[[Category: Gobec, S.]]

[[Category: Gobec S]]

[[Category: Kos, J.]]

[[Category: Kos J]]

[[Category: Mirkovic, B.]]

[[Category: Mirkovic B]]

[[Category: Renko, M.]]

[[Category: Renko M]]

[[Category: Turk, D~~.]]~~

[[Category: Turk D]]

~~[[Category: 8-hydroxy-5-nitroquinoline]]~~

~~[[Category: Cathepsin b]]~~

~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~

~~[[Category: Nitroxoline]]~~

~~[[Category: Reversible inhibitor~~]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_3ai8|  PDB=3ai8  |  SCENE=  }}
-===Cathepsin B in complex with the nitroxoline===
-==Function==
+==Cathepsin B in complex with the nitroxoline==
-[[http://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN]] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
+<StructureSection load='3ai8' size='340' side='right'caption='[[3ai8]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[3ai8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AI8 FirstGlance]. <br>
-[[3ai8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AI8 OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HNQ:5-NITROQUINOLIN-8-OL'>HNQ</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ai8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ai8 OCA], [https://pdbe.org/3ai8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ai8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ai8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ai8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CATB_HUMAN CATB_HUMAN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
 ==See Also==
 *[[Cathepsin|Cathepsin]]
+*[[Cathepsin 3D structures|Cathepsin 3D structures]]
-==Reference==
+__TOC__
-<ref group="xtra">PMID:021598397</ref><references group="xtra"/><references/>
+</StructureSection>
-[[Category: Cathepsin B]]
+[[Category: Homo sapiens]]
-[[Category: Human]]
+[[Category: Large Structures]]
-[[Category: Gobec, S.]]
+[[Category: Gobec S]]
-[[Category: Kos, J.]]
+[[Category: Kos J]]
-[[Category: Mirkovic, B.]]
+[[Category: Mirkovic B]]
-[[Category: Renko, M.]]
+[[Category: Renko M]]
-[[Category: Turk, D.]]
+[[Category: Turk D]]
-[[Category: 8-hydroxy-5-nitroquinoline]]
-[[Category: Cathepsin b]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]
-[[Category: Nitroxoline]]
-[[Category: Reversible inhibitor]]