2mjy: Difference between revisions
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New page: '''Unreleased structure''' The entry 2mjy is ON HOLD Authors: He, Y., Wu, F., Tian, C. Description: Solution structure of synthetic Mamba-1 peptide |
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==Solution structure of synthetic Mamba-1 peptide== | |||
<StructureSection load='2mjy' size='340' side='right'caption='[[2mjy]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mjy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mjy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjy OCA], [https://pdbe.org/2mjy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mjy RCSB], [https://www.ebi.ac.uk/pdbsum/2mjy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjy ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/3SX1_DENPO 3SX1_DENPO] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
An efficient one-pot chemical synthesis of snake venom toxin Mambalgin-1 was achieved using an azide-switch strategy combined with hydrazide-based native chemical ligation. Synthetic Mambalgin-1 exhibited a well-defined structure after sequential folding in vitro. NMR spectroscopy revealed a three-finger toxin family structure, and the synthetic toxin inhibited human acid-sensing ion channel 1a. | |||
One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1.,Pan M, He Y, Wen M, Wu F, Sun D, Li S, Zhang L, Li Y, Tian C Chem Commun (Camb). 2014 Jun 4;50(44):5837-9. doi: 10.1039/c4cc00779d. PMID:24619065<ref>PMID:24619065</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2mjy" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dendroaspis polylepis polylepis]] | |||
[[Category: Large Structures]] | |||
[[Category: He Y]] | |||
[[Category: Tian C]] | |||
[[Category: Wu F]] | |||
Latest revision as of 09:19, 6 November 2024
Solution structure of synthetic Mamba-1 peptide
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