4o9h: Difference between revisions

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'''Unreleased structure'''


The entry 4o9h is ON HOLD until Paper Publication
==Structure of Interleukin-6 in complex with a Camelid Fab fragment==
<StructureSection load='4o9h' size='340' side='right'caption='[[4o9h]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4o9h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O9H FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9h OCA], [https://pdbe.org/4o9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o9h RCSB], [https://www.ebi.ac.uk/pdbsum/4o9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9h ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
== Function ==
[https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.


Authors: Klarenbeek, A., Blanchetot, C., Schragel, G., Sadi, A.S., Ongenae, N., Hemrika, W., Wijdenes, J., Spinelli, S., Desmyter, A., Cambillau, C., Hultberg, A., Kretz-rommel, A., Dreier, T., De_haard, H.J.W., Roovers, R.C.
==See Also==
 
*[[Interleukin 3D structures|Interleukin 3D structures]]
Description: Structure of Interleukin-6 in complex with a Camelid Fab fragment
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Blanchetot C]]
[[Category: Cambillau C]]
[[Category: De haard HJW]]
[[Category: Desmyter A]]
[[Category: Dreier T]]
[[Category: Hemrika W]]
[[Category: Hultberg A]]
[[Category: Klarenbeek A]]
[[Category: Kretz-rommel A]]
[[Category: Ongenae N]]
[[Category: Roovers RC]]
[[Category: Sadi AS]]
[[Category: Schragel G]]
[[Category: Spinelli S]]
[[Category: Wijdenes J]]
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