4lrz: Difference between revisions

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{{STRUCTURE_4lrz|  PDB=4lrz  |  SCENE=  }}
===Crystal Structure of the E.coli DhaR(N)-DhaL complex===
{{ABSTRACT_PUBMED_24440518}}


==Function==
==Crystal Structure of the E.coli DhaR(N)-DhaL complex==
[[http://www.uniprot.org/uniprot/DHAL_ECOLI DHAL_ECOLI]] ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL-ADP receives a phosphoryl group from DhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of DhaR. DhaL-ATP is inactive. [[http://www.uniprot.org/uniprot/DHAR_ECOLI DHAR_ECOLI]] Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own synthesis.  
<StructureSection load='4lrz' size='340' side='right'caption='[[4lrz]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[4lrz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LRZ FirstGlance]. <br>
[[4lrz]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRZ OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrz OCA], [https://pdbe.org/4lrz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lrz RCSB], [https://www.ebi.ac.uk/pdbsum/4lrz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrz ProSAT]</span></td></tr>
<ref group="xtra">PMID:024440518</ref><references group="xtra"/><references/>
</table>
[[Category: Cygler, M.]]
== Function ==
[[Category: Ekiel, I.]]
[https://www.uniprot.org/uniprot/DHAL_ECOLI DHAL_ECOLI] ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL-ADP receives a phosphoryl group from DhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of DhaR. DhaL-ATP is inactive.
[[Category: McDonald, L.]]
__TOC__
[[Category: Shi, R.]]
</StructureSection>
[[Category: Coiled-coil]]
[[Category: Escherichia coli K-12]]
[[Category: Gaf]]
[[Category: Large Structures]]
[[Category: Helix rotation]]
[[Category: Cygler M]]
[[Category: Pa]]
[[Category: Ekiel I]]
[[Category: Transcriptional regulation complex]]
[[Category: McDonald L]]
[[Category: Transferase-transcription regulator complex]]
[[Category: Shi R]]