3b7x: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(14 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:3b7x.gif|left|200px]]<br /><applet load="3b7x" size="350" color="white" frame="true" align="right" spinBox="true"
caption="3b7x, resolution 2.10&Aring;" />
'''Crystal structure of human FK506-Binding Protein 6'''<br />


==About this Structure==
==Crystal structure of human FK506-Binding Protein 6==
3B7X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7X OCA].  
<StructureSection load='3b7x' size='340' side='right'caption='[[3b7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3b7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B7X FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7x OCA], [https://pdbe.org/3b7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7x RCSB], [https://www.ebi.ac.uk/pdbsum/3b7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7x ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/FKBP6_HUMAN FKBP6_HUMAN] Note=FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
== Function ==
[https://www.uniprot.org/uniprot/FKBP6_HUMAN FKBP6_HUMAN] PPIases accelerate the folding of proteins.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/3b7x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b7x ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[FKBP 3D structures|FKBP 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Butler-Cole C]]
[[Category: Butler-Cole, C.]]
[[Category: Davis T]]
[[Category: Davis, T.]]
[[Category: Dhe-Paganon S]]
[[Category: Dhe-Paganon, S.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Paramanathan R]]
[[Category: Paramanathan, R.]]
[[Category: Walker JR]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weigelt J]]
[[Category: Walker, J R.]]
[[Category: Weigelt, J.]]
[[Category: isomerase]]
[[Category: repeat]]
[[Category: rotamase]]
[[Category: sgc]]
[[Category: structural genomics consortium]]
[[Category: tpr repeat]]
[[Category: williams-beuren syndrome]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:03:58 2008''
Retrieved from "https://proteopedia.org/3b7x"