Alpha-lytic protease: Difference between revisions

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<StructureSection load='1p05' size='350' side='right' caption='Structure of alpha-lytic protease complex with boronic acid inhibitor and sulfate (PDB entry [[1p05]])' scene=''>
<StructureSection load='3pro' size='350' side='right' caption='Structure of alpha-lytic protease protease domain (green) and pro domain (magenta) complex with benzenesulfonyl fluoride (PDB entry [[3pro]])' scene='55/551214/Cv/1'>


'''Alpha-lytic protease''' (ALP) is a bacterial serine protease of the chymotrypsin family.  ALP is a two-domain enzyme.  One domain is a large pro region that catalyzes the folding of the protease.  The second domain is the protease domain.
'''Alpha-lytic protease''' (ALP) is a bacterial serine protease of the chymotrypsin family.  ALP is a two-domain enzyme.  One domain is a large pro region (residues 1-199) that catalyzes the folding of the protease.  The second domain is the protease domain (residues 200-397).<ref>PMID:2611204</ref>
*<scene name='55/551214/Cv/4'>ALP protease domain and pro domain complex with benzenesulfonyl fluoride</scene>. Water molecules are shown as red spheres.
*<scene name='55/551214/Cv/5'>Benzenesulfonyl fluoride binding site</scene> (PDB entry [[3pro]]).<ref>PMID:9808037</ref>


== 3D Structures of alpha-lytic protease ==
== 3D Structures of alpha-lytic protease ==
[[Alpha-lytic protease 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>


===ALP protease domain===
== References ==
 
<references/>
[[2alp]], [[1p09]], [[1tal]], [[2ull]], [[1boq]], [[1ssz]], [[2h5c]], [[1ssx]] – LeALP – ''Lysobacter enzymogenes''  <BR />
[[Category: Topic Page]]
[[1gba]], [[1gbe]], [[1gbj]], [[3urc]], [[3urd]], [[3ure]] – LeALP (mutant)  <BR />
[[1p01]], [[1p02]], [[1p03]], [[1p04]], [[1p05]], [[1p06]], [[1p10]], [[2lpr]], [[3lpr]], [[5lpr]], [[6lpr]], [[7lpr]], [[8lpr]], [[9lpr]], [[2h5d]] – LeALP + boronic acid inhibitor  <BR />
[[1gbb]], [[1gbc]], [[1gbd]], [[1gbf]], [[1gbh]], [[1gbi]], [[1gbk]], [[1gbl]], [[1gbm]] – LeALP (mutant) + boronic acid inhibitor  <BR />
[[1p11]], [[1p12]] – LeALP + phosphonate esther inhibitor  <BR />
[[3qgj]] – LeALP + peptide  <BR />
 
===ALP including pro region===
 
[[2pro]], [[1qrx]] – LeALP pro region  <BR />
[[1qq4]], [[1qrw]], [[3m7t]], [[3m7u]] – LeALP pro region (mutant) <BR />
[[3pro]] – LeALP (mutant) + pro region  <BR />
[[4pro]] – LeALP (mutant) + pro region (mutant) <BR />

Latest revision as of 08:31, 6 March 2019

Structure of alpha-lytic protease protease domain (green) and pro domain (magenta) complex with benzenesulfonyl fluoride (PDB entry 3pro)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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