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{{STRUCTURE_2uzq|  PDB=2uzq  |  SCENE=  }}
===Protein Phosphatase, New Crystal Form===
{{ABSTRACT_PUBMED_16342947}}


==About this Structure==
==Protein Phosphatase, New Crystal Form==
[[2uzq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZQ OCA].  
<StructureSection load='2uzq' size='340' side='right'caption='[[2uzq]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2uzq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uzq OCA], [https://pdbe.org/2uzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uzq RCSB], [https://www.ebi.ac.uk/pdbsum/2uzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uzq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MPIP2_HUMAN MPIP2_HUMAN] Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.<ref>PMID:17332740</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uzq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uzq ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Tyrosine phosphatase|Tyrosine phosphatase]]
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
 
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:016342947</ref><references group="xtra"/><references/>
<references/>
[[Category: Human]]
__TOC__
[[Category: Protein-tyrosine-phosphatase]]
</StructureSection>
[[Category: Eberspaecher, U.]]
[[Category: Homo sapiens]]
[[Category: Hillig, R C.]]
[[Category: Large Structures]]
[[Category: Cell cycle]]
[[Category: Eberspaecher U]]
[[Category: Cell division]]
[[Category: Hillig RC]]
[[Category: Dual specificity]]
[[Category: Hydrolase]]
[[Category: Mitosis]]
[[Category: Phosphatase]]
[[Category: Phosphorylation]]
[[Category: Protein phosphatase]]
Retrieved from "https://proteopedia.org/2uzq"