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{{STRUCTURE_4lk9|  PDB=4lk9  |  SCENE=  }}
===Crystal Structure of MOZ double PHD finger histone H3 tail complex===
{{ABSTRACT_PUBMED_24150941}}


==Disease==
==Crystal Structure of MOZ double PHD finger histone H3 tail complex==
[[http://www.uniprot.org/uniprot/KAT6A_HUMAN KAT6A_HUMAN]] Note=Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.  Note=A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein.  
<StructureSection load='4lk9' size='340' side='right'caption='[[4lk9]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4lk9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LK9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lk9 OCA], [https://pdbe.org/4lk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lk9 RCSB], [https://www.ebi.ac.uk/pdbsum/4lk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lk9 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KAT6A_HUMAN KAT6A_HUMAN] Note=Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.  Note=A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein.
== Function ==
[https://www.uniprot.org/uniprot/KAT6A_HUMAN KAT6A_HUMAN] Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.<ref>PMID:11742995</ref> <ref>PMID:11965546</ref> <ref>PMID:12771199</ref> <ref>PMID:16387653</ref> <ref>PMID:17925393</ref>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/KAT6A_HUMAN KAT6A_HUMAN]] Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.<ref>PMID:11742995</ref> <ref>PMID:11965546</ref> <ref>PMID:12771199</ref> <ref>PMID:16387653</ref> <ref>PMID:17925393</ref> 
*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
 
== References ==
==About this Structure==
<references/>
[[4lk9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LK9 OCA].
__TOC__
 
</StructureSection>
==Reference==
[[Category: Homo sapiens]]
<ref group="xtra">PMID:024150941</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Histone acetyltransferase]]
[[Category: Deeves SE]]
[[Category: Human]]
[[Category: Dreveny I]]
[[Category: Deeves, S E.]]
[[Category: Heery DM]]
[[Category: Dreveny, I.]]
[[Category: Yue B]]
[[Category: Heery, D M.]]
[[Category: Yue, B.]]
[[Category: Double phd finger]]
[[Category: Dpf]]
[[Category: H3 tail]]
[[Category: Histone acetyltransferase]]
[[Category: Histone h3]]
[[Category: Plant homeodomain finger]]
[[Category: Transferase]]
[[Category: Zinc finger]]
Retrieved from "https://proteopedia.org/4lk9"