4bws: Difference between revisions

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'''Unreleased structure'''


The entry 4bws is ON HOLD  until Paper Publication
==Crystal structure of the heterotrimer of PQBP1, U5-15kD and U5-52kD.==
<StructureSection load='4bws' size='340' side='right'caption='[[4bws]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4bws]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BWS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bws OCA], [https://pdbe.org/4bws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bws RCSB], [https://www.ebi.ac.uk/pdbsum/4bws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bws ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TXN4A_HUMAN TXN4A_HUMAN] Essential role in pre-mRNA splicing.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A loss-of-function of polyglutamine tract-binding protein 1 (PQBP1) induced by frameshift mutations is believed to cause X-linked mental retardation. However, the mechanism by which structural changes in PQBP1 lead to mental retardation is unknown. Here we present the crystal structure of a C-terminal fragment of PQBP1 in complex with the spliceosomal protein U5-15kD. The U5-15kD hydrophobic groove recognizes a YxxPxxVL motif in PQBP1, and mutations within this motif cause a loss-of-function phenotype of PQBP1 in vitro. The YxxPxxVL motif is absent in all PQBP1 frameshift mutants seen in cases of mental retardation. These results suggest a mechanism by which the loss of the YxxPxxVL motif could lead to the functional defects seen in this type of mental retardation.


Authors: Mizuguchi, M., Obita, T., Serita, T., Kojima, R., Morimoto, T., Nabeshima, Y., Okazawa, H.
Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15kD.,Mizuguchi M, Obita T, Serita T, Kojima R, Nabeshima Y, Okazawa H Nat Commun. 2014 Apr 30;5:3822. doi: 10.1038/ncomms4822. PMID:24781215<ref>PMID:24781215</ref>


Description: Crystal structure of the heterotrimer of PQBP1, U5-15kD and U5-52kD.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4bws" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[U5-15kD|U5-15kD]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Kojima R]]
[[Category: Mizuguchi M]]
[[Category: Morimoto T]]
[[Category: Nabeshima Y]]
[[Category: Obita T]]
[[Category: Okazawa H]]
[[Category: Serita T]]
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