4onl: Difference between revisions
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New page: '''Unreleased structure''' The entry 4onl is ON HOLD Authors: Hodge, C.D., Edwards, R.A., Glover, J.N.M. Description: Crystal structure of human Mms2/Ubc13_D81N,R85S,A122V,N123P |
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==Crystal structure of human Mms2/Ubc13_D81N, R85S, A122V, N123P== | |||
<StructureSection load='4onl' size='340' side='right'caption='[[4onl]], [[Resolution|resolution]] 1.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4onl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ONL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ONL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4onl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4onl OCA], [https://pdbe.org/4onl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4onl RCSB], [https://www.ebi.ac.uk/pdbsum/4onl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4onl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UB2V2_HUMAN UB2V2_HUMAN] Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.<ref>PMID:9705497</ref> <ref>PMID:10089880</ref> <ref>PMID:14562038</ref> <ref>PMID:20061386</ref> | |||
==See Also== | |||
*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Edwards RA]] | |||
[[Category: Glover JNM]] | |||
[[Category: Hodge CD]] | |||
Latest revision as of 12:41, 1 March 2024
Crystal structure of human Mms2/Ubc13_D81N, R85S, A122V, N123P
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