4jlm: Difference between revisions

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{{STRUCTURE_4jlm|  PDB=4jlm  |  SCENE=  }}
===Human dCK C4S-S74E mutant in complex with UDP and the F2.3.1 inhibitor (2-[({5-ETHYL-2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)===
{{ABSTRACT_PUBMED_24419380}}


==Function==
==Human dCK C4S-S74E mutant in complex with UDP and the F2.3.1 inhibitor (2-[({5-ETHYL-2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE)==
[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
<StructureSection load='4jlm' size='340' side='right'caption='[[4jlm]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4jlm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JLM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1NN:2-[({5-ETHYL-2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE'>1NN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jlm OCA], [https://pdbe.org/4jlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jlm RCSB], [https://www.ebi.ac.uk/pdbsum/4jlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jlm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>  


==About this Structure==
==See Also==
[[4jlm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLM OCA].
*[[Deoxycytidine kinase 3D structures|Deoxycytidine kinase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:024419380</ref><references group="xtra"/><references/>
__TOC__
[[Category: Deoxycytidine kinase]]
</StructureSection>
[[Category: Lavie, A.]]
[[Category: Homo sapiens]]
[[Category: Nomme, J.]]
[[Category: Large Structures]]
[[Category: Kinase]]
[[Category: Lavie A]]
[[Category: Phosphoryl transfer]]
[[Category: Nomme J]]
[[Category: Phosphorylation]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4jlm"