4oni: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4oni is ~~ON HOLD until Paper Publication~~

==Structure of Human Orphan Receptor LRH1 bound to two bacterial phospholipids==

== Structural highlights ==

<table><tr><td colspan='2'>[[4oni]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ONI OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4ONI FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P6L:(2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL+(8E)-OCTADEC-8-ENOATE'>P6L</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4oni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oni OCA], [https://pdbe.org/4oni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oni RCSB], [https://www.ebi.ac.uk/pdbsum/4oni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oni ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

~~Authors~~: Gorman~~, M.A., Parker, M.W.,~~ Kusumo, S.

==See Also==

*[[Liver receptor homolog-1|Liver receptor homolog-1]]

~~Description~~: ~~Structure of Human Orphan Receptor LRH1 bound to two bacterial phospholipids~~

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Gorman MA]]

[[Category: Kusumo S]]

[[Category: Parker MW]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4oni is ON HOLD  until Paper Publication
+==Structure of Human Orphan Receptor LRH1 bound to two bacterial phospholipids==
+<StructureSection load='4oni' size='340' side='right'caption='[[4oni]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4oni]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ONI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ONI FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P6L:(2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL+(8E)-OCTADEC-8-ENOATE'>P6L</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oni OCA], [https://pdbe.org/4oni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oni RCSB], [https://www.ebi.ac.uk/pdbsum/4oni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oni ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
-Authors: Gorman, M.A., Parker, M.W., Kusumo, S.
+==See Also==
+*[[Liver receptor homolog-1|Liver receptor homolog-1]]
-Description: Structure of Human Orphan Receptor LRH1 bound to two bacterial phospholipids
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Gorman MA]]
+[[Category: Kusumo S]]
+[[Category: Parker MW]]