4n9d: Difference between revisions

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{{STRUCTURE_4n9d|  PDB=4n9d  |  SCENE=  }}
===Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)===
{{ABSTRACT_PUBMED_24433859}}


==Function==
==Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)==
[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).  
<StructureSection load='4n9d' size='340' side='right'caption='[[4n9d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4n9d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9D FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.701&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HJ:4-({[(4-TERT-BUTYLPHENYL)SULFONYL]AMINO}METHYL)-N-(PYRIDIN-3-YL)BENZAMIDE'>2HJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9d OCA], [https://pdbe.org/4n9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9d RCSB], [https://www.ebi.ac.uk/pdbsum/4n9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).


==About this Structure==
==See Also==
[[4n9d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9D OCA].
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:024433859</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Nicotinamide phosphoribosyltransferase]]
[[Category: Large Structures]]
[[Category: Baumeister, T.]]
[[Category: Baumeister T]]
[[Category: Bravo, B.]]
[[Category: Bravo B]]
[[Category: Brien, T O.]]
[[Category: Dragovich PS]]
[[Category: Dragovich, P S.]]
[[Category: Giannetti AM]]
[[Category: Giannetti, A M.]]
[[Category: Ho Y]]
[[Category: Ho, Y.]]
[[Category: Hua R]]
[[Category: Hua, R.]]
[[Category: Li G]]
[[Category: Li, G.]]
[[Category: Liang X]]
[[Category: Liang, X.]]
[[Category: O'Brien T]]
[[Category: Oh, A.]]
[[Category: Oh A]]
[[Category: Skelton, N J.]]
[[Category: Skelton NJ]]
[[Category: Wang, C.]]
[[Category: Wang C]]
[[Category: Wang, W.]]
[[Category: Wang W]]
[[Category: Wang, Y.]]
[[Category: Wang Y]]
[[Category: Xiao, Y.]]
[[Category: Xiao Y]]
[[Category: Yuen, P.]]
[[Category: Yuen P]]
[[Category: Zak, M.]]
[[Category: Zak M]]
[[Category: Zhao, G.]]
[[Category: Zhao G]]
[[Category: Zhao, Q.]]
[[Category: Zhao Q]]
[[Category: Zheng, X.]]
[[Category: Zheng X]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4n9d"