4n9e: Difference between revisions
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== | ==Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)== | ||
[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN | <StructureSection load='4n9e' size='340' side='right'caption='[[4n9e]], [[Resolution|resolution]] 1.72Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4n9e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HL:1-[(1-BENZOYLPIPERIDIN-4-YL)METHYL]-N-(PYRIDIN-3-YL)-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>2HL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9e OCA], [https://pdbe.org/4n9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9e RCSB], [https://www.ebi.ac.uk/pdbsum/4n9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9e ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | |||
== | ==See Also== | ||
[[ | *[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Baumeister T]] | ||
[[Category: | [[Category: Bravo B]] | ||
[[Category: | [[Category: Dragovich PS]] | ||
[[Category: Dragovich | [[Category: Giannetti AM]] | ||
[[Category: Giannetti | [[Category: Ho Y]] | ||
[[Category: Ho | [[Category: Hua R]] | ||
[[Category: Hua | [[Category: Li G]] | ||
[[Category: Li | [[Category: Liang X]] | ||
[[Category: Liang | [[Category: O'Brien T]] | ||
[[Category: Oh | [[Category: Oh A]] | ||
[[Category: Skelton | [[Category: Skelton NJ]] | ||
[[Category: Wang | [[Category: Wang C]] | ||
[[Category: Wang | [[Category: Wang W]] | ||
[[Category: Wang | [[Category: Wang Y]] | ||
[[Category: Xiao | [[Category: Xiao Y]] | ||
[[Category: Yuen | [[Category: Yuen P]] | ||
[[Category: Zak | [[Category: Zak M]] | ||
[[Category: Zhao | [[Category: Zhao G]] | ||
[[Category: Zhao | [[Category: Zhao Q]] | ||
[[Category: Zheng | [[Category: Zheng X]] | ||
Latest revision as of 12:32, 1 March 2024
Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
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