3wqk: Difference between revisions

==Crystal structure of Rv3378c with PO4==

<StructureSection load='3wqk' size='340' side='right'caption='[[3wqk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>

== Structural highlights ==

<table><tr><td colspan='2'>[[3wqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WQK FirstGlance]. <br>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wqk OCA], [https://pdbe.org/3wqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wqk RCSB], [https://www.ebi.ac.uk/pdbsum/3wqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wqk ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/TUBAT_MYCTU TUBAT_MYCTU] Tuberculosinyl transferase that catalyzes the condensation of adenosine and tuberculosinyl diphosphate (TbPP) to generate 1-tuberculosinyladenosine (1-TbAd), which acts as an antiacid that directly protects M.tuberculosis from acid pH and physically remodels M.tuberculosis phagolysosomes (PubMed:24516143, PubMed:31427817). In addition, acts as a phosphatase that catalyzes the diphosphate-removal from TbPP to produce both tuberculosinol (TOH) and isotuberculosinol (iso-TOH) (PubMed:21228491, PubMed:24475925). Has broad substrate specificity, and can also use the 3 labdadienyl diphosphates, copalyl diphosphate (CDP), ent-CDP and syn-CDP in vitro (PubMed:21290071).<ref>PMID:21228491</ref> <ref>PMID:21290071</ref> <ref>PMID:24475925</ref> <ref>PMID:24516143</ref> <ref>PMID:31427817</ref>

<references/>

</StructureSection>

[[Category: Bogue S]]

[[Category: Chan HC]]

[[Category: Crick DC]]

[[Category: Feng X]]

[[Category: Guo RT]]

[[Category: Hoshino T]]

[[Category: Hu Y]]

[[Category: Huang CH]]

[[Category: Ko TP]]

[[Category: Liang PH]]

[[Category: Liu W]]

[[Category: Lv P]]

[[Category: Nakano C]]

[[Category: Oldfield E]]

[[Category: Wang AH]]

[[Category: Zhang L]]

[[Category: Zheng Y]]