4g2r: Difference between revisions

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{{STRUCTURE_4g2r|  PDB=4g2r  |  SCENE=  }}
===Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor haloxyfop from Mycobacterium tuberculosis===


==About this Structure==
==Crystal Structure of the carboxyltransferase subunit of ACC (AccD6) in complex with inhibitor haloxyfop from Mycobacterium tuberculosis==
[[4g2r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2R OCA].  
<StructureSection load='4g2r' size='340' side='right'caption='[[4g2r]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
[[Category: Propionyl-CoA carboxylase]]
== Structural highlights ==
[[Category: Bruning, J B.]]
<table><tr><td colspan='2'>[[4g2r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2R FirstGlance]. <br>
[[Category: Ehrenfeld, H.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
[[Category: Reddy, M C.M.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H1L:(2R)-2-(4-{[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOXY)PROPANOIC+ACID'>H1L</scene></td></tr>
[[Category: Sacchettini, J C.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2r OCA], [https://pdbe.org/4g2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2r RCSB], [https://www.ebi.ac.uk/pdbsum/4g2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2r ProSAT]</span></td></tr>
[[Category: Sherekar, M.]]
</table>
[[Category: TBSGC, TB Structural Genomics Consortium.]]
== Function ==
[[Category: Thurman, C.]]
[https://www.uniprot.org/uniprot/ACCD6_MYCTU ACCD6_MYCTU] Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit transfers the CO2 from carboxybiotin to the CoA ester substrate (PubMed:17114269). When associated with the alpha3 subunit AccA3, is involved in the carboxylation of acetyl-CoA and propionyl-CoA, with a preference for acetyl-CoA (PubMed:17114269).<ref>PMID:17114269</ref>
[[Category: Valluru, S.]]
== References ==
[[Category: Carboxyltransferase]]
<references/>
[[Category: Crotonase super family]]
__TOC__
[[Category: Structural genomic]]
</StructureSection>
[[Category: Tb structural genomics consortium]]
[[Category: Large Structures]]
[[Category: Tbsgc]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Transferase]]
[[Category: Bruning JB]]
[[Category: Transferase-herbicide complex]]
[[Category: Ehrenfeld H]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Reddy MCM]]
[[Category: Sacchettini JC]]
[[Category: Sherekar M]]
[[Category: Thurman C]]
[[Category: Valluru S]]
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