4npm: Difference between revisions

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~~{{STRUCTURE_4npm| PDB=4npm | SCENE= }}~~

~~===Crystal structure of Zebrafish ALKBH5 in complex with succinic acid===~~

==~~Function~~==

==Crystal structure of Zebrafish ALKBH5 in complex with succinic acid==

[[http://www.uniprot.org/uniprot/ALKB5_DANRE ALKB5_DANRE]] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).

== Structural highlights ==

<table><tr><td colspan='2'>[[4npm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPM OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4NPM FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.803Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4npm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npm OCA], [https://pdbe.org/4npm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4npm RCSB], [https://www.ebi.ac.uk/pdbsum/4npm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4npm ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/ALKB5_DANRE ALKB5_DANRE] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).

==~~About this Structure~~==

==See Also==

[[~~4npm~~]] ~~is a 2 chain structure. Full crystallographic information is available from~~ [~~http~~:~~//oca.weizmann.ac.il/oca-bin/ocashort?id=4NPM OCA~~].

*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]

[[Category: ~~Chen, W.~~]]

__TOC__

[[Category: ~~He, C.~~]]

</StructureSection>

[[Category: ~~Zhang, L.~~]]

[[Category: Danio rerio]]

[[Category: ~~Oxidoreductase~~]]

[[Category: Large Structures]]

[[Category: Chen W]]

[[Category: He C]]

[[Category: Zhang L]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_4npm|  PDB=4npm  |  SCENE=  }}
-===Crystal structure of Zebrafish ALKBH5 in complex with succinic acid===
-==Function==
+==Crystal structure of Zebrafish ALKBH5 in complex with succinic acid==
-[[http://www.uniprot.org/uniprot/ALKB5_DANRE ALKB5_DANRE]] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
+<StructureSection load='4npm' size='340' side='right'caption='[[4npm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4npm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NPM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.803&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4npm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npm OCA], [https://pdbe.org/4npm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4npm RCSB], [https://www.ebi.ac.uk/pdbsum/4npm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4npm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ALKB5_DANRE ALKB5_DANRE] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
-==About this Structure==
+==See Also==
-[[4npm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPM OCA].
+*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
-[[Category: Chen, W.]]
+__TOC__
-[[Category: He, C.]]
+</StructureSection>
-[[Category: Zhang, L.]]
+[[Category: Danio rerio]]
-[[Category: Oxidoreductase]]
+[[Category: Large Structures]]
+[[Category: Chen W]]
+[[Category: He C]]
+[[Category: Zhang L]]